ApiDB represents a unified entry point for the NIH-funded Apicomplexan Bioinformatics Resource Center (BRC) that integrates numerous database resources and multiple data types. The phylum Apicomplexa comprises numerous veterinary and medically important parasitic protozoa including human pathogenic species of the genera Cryptosporidium, Plasmodium, Giardia, Trichomonas, and Toxoplasma. ApiDB serves not only as a database in its own right, but as a single web-based point of entry that unifies access to three major existing individual organism databases (PlasmoDB, ToxoDB and CryptoDB), and integrates these databases with data available from additional sources. Through the ApiDB site, users may pose queries and search all available apicomplexan data and tools, or they may visit individual component organism databases.

Biodefense/Public Health DataBase (BioHealthBase) is a Bioinformatics Resource Center (BRC) for Biodefense and Emerging/Re-emerging Infectious Diseases whose mission is to assist scientific researchers in the development of vaccines, therapeutics, and diagnostics for a select subset of Category A - C pathogens. The BioHealthBase BRC focuses on six priority pathogens to help fill in gaps in genomic and other data critical to scientific researchers. The six pathogens are Francisella tularensis bacteria; Influenza (flu) virus; Mycobacterium tuberculosis (TB) bacteria; Microsporidia parasites; Giardia lamblia (giardiasis) parasite; and Ricinus communis (castor bean) plant. The organisms were selected to represent a cross-section of the major groups of human pathogens, including bacteria, viruses, protozoan parasites and plants (toxins).

The Enteropathogen Resource Integration Center (ERIC) BRC project is funded to cover five enterobacterial pathogens: diarrheagenic Escherichia coli, Shigella spp., Salmonella spp., Yersinia enterocolitica, and Yersinia pestis. The primary objective for ERIC will be to provide integrated access to both data and analysis tools. As much as possible, ERIC will adapt an Open Source software approach and will emphasize integration and reuse of existing tools, for the single greatest problem in bioinformatics remains the need to integrate data and tools to work together seamlessly. The goals for this BRC are straightforward - ERIC intends to provide the best annotated enterobacterial genomes and information available, accessed through a comprehensive, easy to use, open web portal uniting biological data and analysis tools.

The National Microbial Pathogen Data Resource (NMPDR) is a NIAID-funded Bioinformatics Resource Center that supports research in selected Category B pathogens. NMPDR contains the complete genomes of ~50 strains of pathogenic bacteria that are the focus of our curators, as well as >400 other genomes that provide a broad context for comparative analysis across the three phylogenetic Domains.

As an NIAID Bioinformatics Resource Center (BRC) Pathema contains in depth curatorial analysis of six target organisms from the list of NIAID category A-C pathogens. Pathema also offers single-genome and comparative multi-genome analyses as well as display tools at the genome, gene, and pathway level for these pathogens.

Pathema also offers single-genome and comparative multi-genome analyses as well as display tools at the genome, gene, and pathway level for these pathogens as well as display tools at the genome, gene, and pathway level for these pathogens.

PATRIC, the PathoSystems Resource Integration Center, is a multi-faceted bioinformatic website containing genomic and associated information on the eight important human pathogens. This project seeks to integrate genomics with comparative genomics and pathway analysis and ultimately proteomics, transcriptomics, immune epitope mapping, host-response and other downstream technologies. The goal is to help researchers and clinicians better detect and respond to biothreat agents (and infectious diseases in general) by facilitating the development of diagnostics, vaccines and therapeutics. This requires access to comprehensive information on the molecular biology, physiology and pathogenicity of these organisms.

The Viral Bioinformatics Resource Center (VBRC) at the University of Alabama at Birmingham and the University of Victoria is one of eight NIH/NIAID-funded Bioinformatics Resource Centers nationwide providing comprehensive web-based genomics resources to the scientific community conducting basic and applied research on microorganisms selected from the NIH/NIAID Category A, B, and C priority pathogens that are regarded as possible bioterrorist threats or as emerging or re-emerging infectious diseases. The VBRC is concerned primarily with viruses encompassing the families Arenaviridae, Bunyaviridae, Flaviviridae, Filoviridae, Paramyxoviridae, Poxviridae, and Togaviridae.

VectorBase is a web-accessible data repository for information about invertebrate vectors of human pathogens. VectorBase annotates and maintains vector genomes providing an integrated resource for the research community. Currently, VectorBase contains genome information for two organisms: Anopheles gambiae, a vector for the Plasmodium protozoan agent causing malaria, and Aedes aegypti, a vector for the flaviviral agents causing Yellow fever and Dengue fever.